Study Shows Gut-Calming Effects Of Chili Peppers And Marijuana

Cornelia Mascio
Aprile 27, 2017

Further investigation revealed that anandamide not only interacts with TRPV1 in order to produce more anandamide, but it also works with a receptor called CX3CR1, which recruits a type of macrophage - or white blood cell - that reduces inflammation. Mice with type 1 diabetes were actually cured by eating chili pepper.

Active ingredients in chili peppers and cannabis help gut inflammation subside, and these findings could lead to new therapies for diabetes and colitis.

"Touch a chili pepper to your mouth and you feel heat", states a UConn press release.

The team notes that anandamide is chemically comparable to the compounds found in marijuana, and it binds to cannabinoid receptors in the brain.

This is the first time a major immune function has been identified for cannabinoids, which could mean your digestive and nervous systems are involved in something of a biological correspondence based on these shared receptors, according to Srivastava.

Srivastava and his colleagues don't know how or why anandamide might relay messages between the immune system and the brain, but they have learned the details of how it heals the gut.

The researchers found it was the anandamide that reduced inflammation in the mice's gut, calming their immune system down, so they tested feeding the anandamide directly to the mice and found the same thing happened. The same gut-calming results were observed by feeding the mice anandamide directly, as reported in Proceedings of the National Academy of Sciences. "They share a common language", says Srivastava. And one word of that common language is anandamide. When anandamide levels increase, the macrophage population and activity level also increases. The effects pervade the entire upper gut, including the esophagus, stomach and pancreas. Currently, the investigators are working with mouse models to determine whether it affects disorders such as colitis. How does ingesting weed affect the gut and the brain?

It's hard to get a federal license to experiment with marijuana on people in the United States, but UConn researchers are looking at possibly contacting those states where marijuana has been legalized to do studies on cannabinoids and the effects of regular marijuana use on the gastrointestinal system, reports Inverse.

The researchers hope that further study can be carried out using marijuana, though the fact it's not legal in some states in the USA makes it hard to get a federal license to study the effects that consuming marijuana could have on the digestive system.

"If the epidemiological data shows a significant change [since marijuana legalization in 2012], that would make a testable case that anandamide or other cannabinoids could be used as therapeutic drugs to treat certain disorders of the stomach, pancreas, intestines, and colon".

While chili peppers and marijuana have very different effects on the brain, a new study shows that, when consumed, their impact on the gut may not be so dissimilar. But how useful if it's true.

Altre relazioniGrafFiotech

Discuti questo articolo

Segui i nostri GIORNALE