New Research Says High Fat Diet May Promote Weight Loss

Modesto Morganelli
Dicembre 7, 2017

A cheery amazement for the people wishing to eat fatty diets and lose weight, simultaneously, as a team of scientists have recognized a way to prevent fat cells from developing larger, which leads to obesity and weight gain.

Researchers from the Washington University School of Medicine located in the St. Louis, United States, have concluded the result by triggering the Hedgehog pathway in the fat cells of mice they that they could feed them high fat diet despite of making them fat.

"More importantly, when we did metabolic studies, we found that the animals with the active Hedgehog pathway not only were leaner, they also had lower blood-glucose levels and were more sensitive to insulin", says Long. "What's particularly important is that the animals in our study ate a high-fat diet but didn't gain weight, and in people, too much fat in the diet is a common cause of obesity".

The researchers say the Hedgehog pathway keeps the fat cells from growing beyond a certain size. But the mice that had been engineered with genes to activate the pathway didn't gain any more weight than did control animals that consumed normal diets.

According to the researchers, the pathway discovered by the team may act as a new therapeutic target for treating obesity.

The Hedgehog pathway prevented obesity by inhibiting the size of the fat cells, Long said. A person gains weight mainly because fat cells get bigger, as opposed to having more fat cells.

By stimulating Hedgehog and related proteins in fat cells, the researchers kept the animals' fat cells from collecting and storing fat droplets. "If we can come up with strategies to carefully target fat cells, then I think activating this pathway could be effective in the fight against obesity", he said.

About a third of American adults is obese, the study in the journal eLife explains, and it is about more than just physical appearance - obesity has been linked to serious health problems like cardiovascular disease and diabetes.

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