New 'Cancer Vaccine' Attacks Tumors From Within

Modesto Morganelli
Aprile 11, 2019

Last Updated: April 09, 2019.

Although the treatment doesn't prevent cancer like other vaccines, researchers refer to it as one because it makes a body's immune system fight the disease.

The treatment "has broad implications for multiple types of cancer", said lead author, Dr. Joshua Brody, director of the lymphoma immunotherapy program. He is director of the Lymphoma Immunotherapy Program at the Icahn School of Medicine at Mount Sinai in New York City. This method injects immune stimulants directly into a tumor.

The vaccine also halted overall cancer progression in six patients for three to 18 months, and caused significant regression or actual remission in three patients, the investigators found.

The procedure was conducted on patients with advanced-stage lymphoma who were also part of some trials involving head and neck and breast cancer. That trial started in March.

Through this process, the immune cells learned which cells to kill and could continue to kill them throughout the body. The dendritic cells take up the antigens and show them to the T cells to help them learn.

But the checkpoint inhibitors have typically only been able to help about one in five cancer patients significantly, "so there's lots of room for improvement", he added.

This new vaccine approach focuses on dendritic cells, which Brody calls the "generals" of the immune system's army.

"The dendritic cells are learning the lesson ... and telling it to the T-cells", Dr. Brody told the publication. A second injection then contains a molecule to activate the dendritic cells, Live Science reported. These cells then instruct T-cells to attack tumors in a person's body, like generals instructing soldiers how to fight.

Researchers created the treatment directly inside the tumor. The method is called vaccine because, although not preventive like the flu shot, it stimulates the immune system to fight the problem. On lab mice the team of researchers used both the vaccine and the check point blockade and saw a promising result in cancer cell killing with 75 percent mice being in remission from cancer after the experiment.

Scientists have seemingly found a way to control cancer in certain situations after a team from Mount Sinai Hospital in NY developed a new take on cancer immunotherapy methods.

"Additional human studies are warranted to confirm these findings", Greer said.

A potential "vaccine" for cancer has shown positive results in a recent clinical trial involving nearly a dozen lymphoma patients, CNBC reports. Celldex and Oncovir provided the materials for the clinical trial and lab work. "The fact there was stable disease doesn't really mean anything because these cancers don't grow fast".

The American Cancer Society has more about cancer immunotherapy.

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