US Task Force Issues Updated Guidelines on PrEP Use, HIV Screening

Modesto Morganelli
Giugno 14, 2019

Based on these findings, the USPSTF concluded that "the magnitude of benefit of PrEP with oral tenofovir disoproxil fumarate-based therapy to reduce the risk of acquisition of HIV infection in persons at high risk is substantial".

"It will dramatically encourage PrEP use and will help force price reductions that are a major current barrier to this essential HIV prevention tool", Volberding, coauthor of an editorial accompanying the recommendations in JAMA, said by email.

The task force said PrEP is only for people at high risk of infection.

"There are highly effective preventive interventions that can help us toward the goal of ending the HIV epidemic in the USA", said Owens, who is also an investigator at VA Palo Alto Health Care System "However, we know not enough people receive these interventions".

Furthermore, the new guidelines recommend that health professionals offer PrEP to those at high risk of HIV transmission - specifically gay and bisexual men, those who report having condomless sex, who've had a recent STI, who have an HIV-positive sex partner, straight folks with high-risk sex practices, injection drug users, sex workers, as well as transgender people.

Currently, 1.1 million people are living with HIV in the U.S.

Results showed that use of PrEP reduced the risk of HIV infection compared with placebo or no PrEP (relative risk [RR], 0.46 [95% CI, 0.33-0.66]; absolute risk reduction, -2.0% [95% CI, -2.8% to -1.2%]).

PrEP can lower the risk of getting HIV from sex by up to 90%, according to the CDC.

Truvada, the only FDA-approved drug sold as PrEP, has seen uphill battles in the last few months due to its high market price of almost $3,000 per month. The FDA approved PrEP for HIV prevention in 2012. "PrEP is highly effective if taken as indicated".

There's little downside to taking PrEP. Although there are clear benefits, the task force also found adequate evidence that PrEP is associated with small harms, including kidney and gastrointestinal adverse effects. There is also some concern that PrEP may increase the spread of other sexually transmitted infections if users decrease condom use because they mistakenly believe the pill protects against those diseases, too. The U.S. Preventive Services Task Force usually advice that everyone ages between 15 to 65 and any pregnant woman should be regularly screened, though the latest recommendation is a step ahead to cure the disease at the initiation stage.

Less than half of USA adults have been screened for HIV, and screening rates are low even among high-risk individuals like injection drug users, according to the CDC.

The task force is an independent, volunteer panel of national experts in prevention and evidence-based medicine who work to improve the health of all Americans by making recommendations.

Altre relazioniGrafFiotech

Discuti questo articolo

Segui i nostri GIORNALE